International mRCC Database Consortium

Working Together Against Kidney Cancer

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IMDC Risk Calculator

Karnofsky Performance status

Is the Karnofsky Performance status < 80%?

Karnofsky Performance Status <80% is roughly equivalent to ECOG Performance status ≥ 2

No

Yes

Time from diagnosis to treatment

Has it been < 1 year from time of diagnosis to systemic therapy?

Time from any initial diagnosis (including localized RCC) to when first systemic therapy is started for metastatic disease

No

Yes

Hemoglobin < Lower limit of normal

Usually ~120 g/L (12.0 mg/dL) for females and ~135 g/L (13.5 mg/dL) for males*

No

Yes

Neutrophils > Upper limit of normal

Usually ~7-8 x 109/L or 7000-8000/mm3*

No

Yes

Platelets > Upper limit of normal

Usually ~400-450 cells/µL*

No

Yes

Corrected Calcium > Upper limit of normal

Usually ~2.6 mmol/L or ~ 10.6 mg/dL*

No

Yes

First line

Second line

Third line

Fourth Line

First line non-clear-cell

Favourable risk

0 factors

Median Survival:

43 months

*Because normal ranges vary between laboratories, use limits of normal set by the laboratory performing the tests.

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